教师名录

司伟副教授博士生导师,硕士生导师
所在院系:医学装备系
办公室:机械楼 357
电话:
邮箱:wei.si@seu.edu.cn
个人简介

欢迎优秀的本科生、研究生来课题组垂询体验(例如:竞赛、SRTP项目、毕业设计和攻读研究生学位等),课题组将为各位同学提供个性化的发展规划和优厚的助研津贴与绩效奖励,简历投递邮箱地址wei.si@seu.edu.cn

 

司伟博士,副教授,博导/硕导,医学装备系主任,江苏省优青、江苏省青托,东南大学至善青年学者(A/B层次),江苏省优秀博士学位论文和东南大学优秀博士学位论文获得者,入选东南大学机械工程学院优才培育计划,担任《MaterialsInternational(ISSN: 2668-5728)期刊助理编辑和《Bioengineering International(ISSN 2668-7119)期刊编委。获Nanotechnology期刊杰出审稿人奖、3M Nano国际会议最佳论文奖指导教师、“Electrophoresis” 期刊Reviewer CertificateIOP Trusted Reviewer、闵瑜校友奖励基金等。

主要研究方向:微纳尺度下的(1)机械操控及机器人技术、(2)流体动力学及传感器、(3)结构工艺设计及加工制造、(4)程序语言算法和三维建模与仿真。

教学方面:东南大学第二届“杰出教学奖”教学新秀奖、东南大学第28届青年教师授课竞赛二等奖(每年约前5%可入围)、首届东南大学教师教学创新大赛三等奖,作为项目负责人承担校级教改项目2项,已发表教改论文3篇,担任东南大学机械工程学院本科生班主任,担任东南大学学习优秀生指导教师,担任本科生大类培养指导教师,担任铸造工艺大赛、CIMC“西门子杯中国智能制造挑战赛、本科生工程训练综合能力竞赛指导教师并获得国家级、省部级奖多项,所带的本科毕业设计获得东南大学本科生优秀毕业设计(论文)团队称号,所带的多届本科生毕业设计论文获得机械学院优秀毕业设计论文,所带的本科生SRTP项目获得省级SRTP项目支持,所带的本科班级团支部获东南大学磐石计划校级项目立项。

科研方面:Journal of the American Chemical SocietyACS NanoSmallSmallMethods等国内外期刊发表SCI论文48篇,EI论文23篇,申请和授权发明专利17项,其中以第一作者在ACS NanoSmallSmallMethods等国内外期刊发表SCI论文24(包括IF>10.0SCI论文6篇,封面论文3)。近年来作为主持人承担国家自然科学基金面上项目、国家自然科学青年基金、江苏省基础研究计划(自然科学基金)优秀青年基金、江苏省基础研究计划(自然科学基金)青年基金、江苏省科协青年科技人才托举工程资助项目、南京市留学人员科技创新项目、江苏省仪器仪表学会智能医疗器械创新基金和校企合作基金等多个项目;作为参与人参加研究国家重点研发计划1项,国家自然科学基金重点基金2项和面上基金3项。国际国内作大会报告9次,特邀报告5次。

个人学术主页1https://orcid.org/0000-0001-7285-058X  

个人学术主页2https://www.researchgate.net/profile/Wei-Si-4/research

个人学术主页3https://scholar.google.com/citations?user=J4R73XEAAAAJ&hl=en

五篇代表作(通讯作者论文加*

1.    Si, W.*;Yu, M.; Wu, G.;Chen,  C.; Sha, J.; Zhang, Y.; Chen, Y.,A Nanoparticle-DNA Assembled Nanorobot Powered by Charge-Tunable Quad-Nanopore System. ACS Nano 2020, 14 (11),  15349-15360. (IF17.1)

2.    Si, W.; Aksimentiev, A.,Nanopore  Sensing of Protein Folding. ACSNano 2017,11 (7), 7091-7100. (IF17.1)

3.    Si, W. *; Zhang, Y.; Wu, G.;Kan, Y.; Zhang,  Y.; Sha, J.; Chen, Y.,Discrimination of Protein Amino Acid or Its Protonated  State at Single-Residue Resolution byGraphene Nanopores. Small 2019,15 (14), e1900036. (IF13.3)

4.    Si, W.*; Sun, Q.; Chen,  C.; Yu, M.; Sha, J.; Zhang, Y.; Kan, Y.;Chen, Y., Detergent-Assisted Braking  ofPeptide Translocation through a Single-Layer Molybdenum Disulfide  Nanopore. Small Methods 2020, 1900822.( (IF12.4,封面论文)

5.    Si, W.*; Zhu, Z.; Wu, G.;Zhang, Y.; Chen, Y.; Sha, J. Encoding Manipulation of DNA‐NanoparticleAssembled Nanorobot Using Independently Charged Array Nanopores. Small Methods2022, 6(8): e2200318. (IF12.4)

特邀报告情况:

1.    司伟纳米孔内的流场力及其在纳米机器人驱动中的应用,首届力学交叉前沿研究论坛, 2023-4-212023-4-23,江苏省南京市(大会特邀报告)

2.    司伟基于纳通道的微纳米流体传感与驱动技术,第十六届全国压电和声波理论及器件应用研讨会, 2022-10-112022-10-14,江苏省南京市(大会特邀报告)

3.     司伟DNA过孔操控辅助下的纳米孔测序技术,第一届东南大学先进传感与智能制造国际青年学者论坛,2021-10-292021-10-31,江苏省南京市(大会分会场主席、特邀报告)

4.     Si, W.Controlled translocation of DNA throughsolid-state nanopores for sequencing and manipulation Si, Wei 2021 NanoporeWeekly Meeting, 2021-7-192021-7-19,online(大会特邀报告)

5.     司伟,纳米孔限域在基因类疾病诊疗中的应用,第四届青年科学家论坛——“微纳制造与微纳机器人技术2019614日-16日,黑龙江省哈尔滨工业大学。(大会特邀报告)

其他参加学术会议情况:

6.    司伟纳尺度下的分子运动操控技术,第七届中国微米纳米技术应用创新大会,2022-8-62022-8-8,浙江省杭州市(大会报告)

7.    司伟微纳流体中的单分子驱动操控及纳米机器人研制,中国微米纳米技术学会第五届微流控技术应用创新论坛,2022-7-272022-7-29,广东省广州市(大会报告)

8.       Si, W.; Aksimentiev, A. Nanopore Sensing ofProtein Shape and Folding-Unfolding Transitions. First Conference on Biomotors,Virus Assembly, and Nanobiotecgnology Applications, August 16-19, 2017,Columbus, OH, USA. (Oral presentation)

9.      Si, W.; Aksimentiev, A. Nanopore Ionic Current Can Report on the Folding State of aProtein[J]. Biophysical Society 61stAnnual Meeting, February 11-15, 2017. New Orleans, Louisiana, United States. (Poster presentation)

10.   Si, W.; Yang, H.; Ji, A.; Li,K.; Sha, J.; Liu, L.; Chen, Y. Electrophoresis ofpoly(dT)20 through -hemolysin nanopore in high concentrationpotassium chloride solution. The 17th Annual Conference and 6thInternational Conference of the Chinese Society of Micro-Nano Technology,October 11-14, 2015, Shanghai, China. (Poster presentation)

11.   Si, W.; Sha, J.; Liu,L.; Zhang, Y.; Chen, Y. The Molecular Dynamics Study for Detection of Ssdna byMonolayer Graphene Nanopore[C]. in ASME 2013 International MechanicalEngineering Congress and Exposition, IMECE 2013, November 15, 2013 - November21, 2013. 2013. San Diego, CA, United states: American Society of MechanicalEngineers (ASME). ASME.(Oral presentation)

12.   Si, W.; Sha, J.; Liu, L.; Li,J.; Ge, Y.; Chen, Y., Mechanisms of Pressure-induced water infiltration processthrough graphene nanopores. The 6th Asia-Pacific Conference on Transducersand Micro/Nano Technologies, July 8-11, 2012, Nanjing, China. (Poster presentation)

13.   Si, W.; Sha, J. J.; Liu, L.;Li, J. P.; Wei, X. L.; Chen, Y. F. Detecting DNA Using a Single Graphene Poreby Molecular Dynamics Simulations. 13th Annual Conference of theChinese Socirty of Micro-Nano Technology, September 28-30, 2011, Changzhou, China. (Posterpresentation)


学习经历
工作经历

202104-至今 ,东南大学,机械工程学院,副教授,硕导/博导

201806-202103月,东南大学,机械工程学院,讲师,硕导

教授课程

1.机械设计基础(56学时,本科生课程)

2.设计原理与方法II48学时,本科生课程)

3.工程创新体验课(32学时,本科生课程)

4.微纳机电系统(全英文,48学时,本科生课程)

5.高等机构学32学时,研究生课程)


研究方向
微纳尺度下的(1)机械操控及机器人技术、(2)流体动力学及传感器、(3)结构工艺设计及加工制造、(4)程序语言算法和三维建模与仿真。
审稿期刊

1.    ChemicalScience

2.    ACSApplied Materials & Interfaces

3.    ACSSensors

4.    Nanoscale

5.    Nanotechnology

6.    Journalof Polymer Science

7.    Journalof Physics D-Applied Physics

8.    Journalof Physics-Condensed Matter

9.    Langmuir

10.  ModernPhysics Letters B

11.  PhysicaScripta

12.  Electrophoresis

13.  ChineseJournal of Chemistry

14.  Polymer

15.  Frontiersin Chemistry

16.  IETNanobiotechnology

学术兼职

1.MaterialsInternational(ISSN: 2668-5728)期刊助理编辑

2.《BioengineeringInternational(ISSN 2668-7119)期刊编委


获奖情况

1.    2022Electrophoresis Reviewer Certificate

2.    2022年闵瑜校友奖励基金

3.    20223M Nano国际会议最佳学生论文奖指导教师

4.    2021年东南大学第28届青年教师授课竞赛二等奖(每年约前5%可入围)

5.    2021年首届东南大学教师教学创新大赛三等奖

6.    2020年东南大学至善青年学者B层次)

7.    2020Nanotechnology期刊最佳审稿人奖

8.    2020年东南大学机械工程学院优才培育计

9.    2019年东南大学机械工程学院优才培育计

10.  2019年江苏省优秀博士学位论文

11.  2019年东南大学优秀博士学位论文


论文著作

第一作者或通讯作者教学论文(通讯作者论文加*

1.    司伟*,工科专业课教学中课程思政与启发式教学的有机融合. 教书育人(高教论坛) 2021, 110-112.

2.    司伟*,工科专业课程中教师思政教学的意识培养与能力提升. 教书育人(高教论坛)2021, No.760, 45-47.

3.    司伟*,机械设计课堂中的启发式引导教学. 面向一流课程建设的机械原理课程内涵发展与质量提升 2021, 204-206.

第一作者或通讯作者SCI论文(通讯作者论文加*

1.    Si, W.*; Wang, L.; Lin, X.; Wu,G.; Zhang, Y.; Sha, J. A controllable nanoscale telescopic arm designed byencoding the nested multi-walled carbon nanotubes. Phys. Chem. Chem. Phys.2023, 25, 11805-11815.

2.    Ma,C.; Xu, W.; Liu, W.; Xu, C.; Si, W.*;Sha, J. Precise control of CNT-DNA assembled nanomotor using oppositely chargeddual nanopores. Nanoscale 2023, 15, 11052-11063.

3.    Si, W.*; Lin, X.; Wang, L.; Wu,G.; Zhang, Y.; Chen, Y.; Sha, J. Nanopore actuation of a DNA-trackednanovehicle. Nanoscale 2023, 15, 14659-14668.

4.    Si, W.*; Zhu, Z.; Wu, G.;Zhang, Y.; Chen, Y.; Sha, J. Encoding Manipulation of DNA‐NanoparticleAssembled Nanorobot Using Independently Charged Array Nanopores. Small Methods 2022,6(8): e2200318.

5.    Si, W.*; Yuan, R.; Wu, G.; Kan,Y.; Sha, J.; Chen, Y.; Zhang, Y.; Shen, Y. Navigated Delivery of Peptide to theNanopore Using In-Plane Heterostructures of MoS2 and SnS2 for ProteinSequencing. J. Phys. Chem. Lett. 2022, 3863-3872.

6.    Yu,M. #; Si, W. *##并列一作); Zeng, T. #; Chen, C.; Lin, X.;Ji, Z.; Guo, F.; Li, Y.; Sha, J.; Dong, Y. Unveiling the Microscopic Mechanismof Current Variation in the Sensing Region of the MspA Nanopore for DNASequencing. J. Phys. Chem. Lett. 12(37): 9132-9141.

7.    Si, W.*; Yang, H.; Wu, G.;Zhang, Y.; Sha, J. Velocity control of protein translocation through a nanoporeby tuning the fraction of benzenoid residues. Nanoscale 2021, 13(36):15352-15361.

8.    Si, W.*; Chen, C.; Wu, G.; Sun,Q.; Yu, M.; Qiao, Y.; Sha, J. High Efficient Seawater Desalination Based onParallel Nanopore Systems. Nano 2021, 16, 2150077.

9.    Si, W.*;Yu, M.; Wu, G.;Chen,  C.; Sha, J.; Zhang, Y.; Chen, Y.,A Nanoparticle-DNA Assembled Nanorobot Powered by Charge-Tunable Quad-Nanopore System. ACS Nano 2020, 14 (11),  15349-15360.

10.  Si, W.*; Sun, Q.; Chen,  C.; Yu, M.; Sha, J.; Zhang, Y.; Kan, Y.;Chen, Y., Detergent-Assisted Braking  ofPeptide Translocation through a Single-Layer Molybdenum Disulfide  Nanopore. Small Methods 2020, 1900822.(封面论文)

11.  Si, W.*; Yang, H.;  Wu, G.; Chen, C.; Yu, M., Manipulation of DNAtransport through solid-state  nanoporesby atomic force microscopy. Materials Research Express 2020,7 (9), 095404.

12.  Liu,C. #; Si, W. ##并列一作); Wu, C.#; Yang, J.;  Chen, Y.; Dames, C., The ignored effects ofvibrational entropy and  electrocaloriceffect in PbTiO3 and PbZr0.5Ti0.5O3 as studied through  first-principles calculation. Acta Materialia2020,191,  221-229.

13.  Si, W.; Sha, J.; Sun, Q.; He,Z.; Wu, L.; Chen, C.; Yu,  S.-H.; Chen,Y., Shape Characterization and Discrimination of Single  Nanoparticles using Solid-state Nanopores.Analyst 2020,145 (5), 1657-1666. (封面论文)

14.  Si, W.*; Liu, C.; Sha, J.;Zhang, Y.; Chen, Y., Computational modeling of ionic currents through difform graphene nanopores withconsistent  cross-sectional areas. Phys.Chem. Chem. Phys. 2019,21  (47),26166-26174.

15.  Si, W. *; Zhang, Y.; Wu, G.;Kan, Y.; Zhang,  Y.; Sha, J.; Chen, Y.,Discrimination of Protein Amino Acid or Its Protonated  State at Single-Residue Resolution byGraphene Nanopores. Small 2019,15 (14), e1900036.

16.  Si, W.; Yang, H.; Sha, J.;Zhang,  Y.; Chen, Y., Discrimination ofsingle-stranded DNA homopolymers by sieving out G-quadruplex using tiny solid-state nanopores. Electrophoresis 2019,40(16-17), 2117-2124.(封面论文)

17.  Si, W. *; Zhang, Y.; Sha, J. J.;Chen, Y.  F., Mechanisms ofpressure-induced water infiltration process through  graphene nanopores. Mol Simulat 2019,45 (6),518-524.

18.  Si, W.*; Zhang, Y.; Sha, J.;Chen, Y.,  Controllable and reversibleDNA translocation through a single-layer molybdenum disulfide nanopore. Nanoscale 2018,10 (41), 19450-19458.

19.  Sha,J.#; Si, W.##并列一作); Xu, B.; Zhang, S.; Li, K.; Lin, K.; Shi, H.; Chen, Y., Identificationof  Spherical and Nonspherical Proteinsby a Solid-State Nanopore. Anal. Chem. 2018,90 (23),  13826-13831.

20.  Si, W.; Yang, H. J.; Li, K.;Wu,  G. S.; Zhang, Y.; Kan, Y. J.; Xie,X.; Sha, J. J.; Liu, L.; Chen, Y. F., Investigation on the interaction length and access resistance of ananopore  with an atomic forcemicroscopy. Science  China-TechnologicalSciences 2017,60 (4), 552-560.

21.  Si, W.; Aksimentiev, A.,Nanopore  Sensing of Protein Folding. ACSNano 2017,11 (7), 7091-7100.

22.  Si, W.; Aksimentiev, A.,Nanopore  Ionic Current can Report on theFolding State of a Protein. Biophys. J. 2017,112 (3),  195a-195a.

23.  Cressiot,B.#; Greive, S. J.#; Si, W#.#并列一作); Pascoa, T. C.; Mojtabavi,M.;  Chechik, M.; Jenkins, H. T.; Lu, X.;Zhang, K.; Aksimentiev, A.; Antson, A. A.; Wanunu, M., Porphyrin-Assisted Docking of a Thermophage Portal Protein  into Lipid Bilayers: Nanopore Engineering andCharacterization. ACS Nano 2017,11 (12), 11931-11945.

24.  Si, W.; Zhang, Y.; Wu, G. S.;Sha,  J. J.; Liu, L.; Chen, Y. F., DNAsequencing technology based on nanopore sensors by theoretical calculations and simulations. Chinese Science Bulletin2014,59 (35), 4929-4941.

25.  Si, W.; Sha, J. J.; Liu, L.;Qiu,  Y. H.; Chen, Y. F., Effect ofnanopore size on poly(dT)(30) translocation through silicon nitride membrane. Sci. China: Technol. Sci. 2013,56 (10), 2398-2402.

第一作者或通讯作者EI论文(通讯作者论文加*

26.  Zhu,Z.; Si, W.* In Analysis ofElectroosmotic Drive of Double Nanopore Structure, 2022 IEEE InternationalConference on Manipulation, Manufacturing and Measurement on the Nanoscale,3M-NANO 2022, August 8, 2022 - August 12, 2022, Tianjin, China, Institute ofElectrical and Electronics Engineers Inc.: Tianjin, China, 2022; pp 340-343.

27.  Yuan,R.; Si, W.* In ProteinUnfolding with MoS2/SnS2Heterostructure, 2022 IEEE International Conference onManipulation, Manufacturing and Measurement on the Nanoscale, 3M-NANO 2022,August 8, 2022 - August 12, 2022, Tianjin, China, Institute of Electrical andElectronics Engineers Inc.: Tianjin, China, 2022; pp 478-481.

28.  Wang,L.; Si, W.* In The HinderingEffect of the Electric Double Layer during the Retraction of the Inner Wall ofa DWCNT, 2022 IEEE International Conference on Manipulation, Manufacturing andMeasurement on the Nanoscale, 3M-NANO 2022, August 8, 2022 - August 12, 2022,Tianjin, China, Institute of Electrical and Electronics Engineers Inc.:Tianjin, China, 2022; pp 487-490.

29.  Lin,X.; Si, W.* In IonicTransport through Double Nanopores through Simulation, 2022 IEEE InternationalConference on Manipulation, Manufacturing and Measurement on the Nanoscale,3M-NANO 2022, August 8, 2022 - August 12, 2022, Tianjin, China, Institute ofElectrical and Electronics Engineers Inc.: Tianjin, China, 2022; pp 499-502.

30.  Yu,M.; Si, W.*; Sha, J. InMolecular Dynamics Simulation for Protein Unfolding, 2020 IEEE 15thInternational Conference on Nano/Micro Engineered and Molecular System (NEMS),27-30 Sept. 2020; 2020; pp 382-386.

31.  Si, W.; Yang, H.; Ji, A.; Li,K.;  Sha, J.; Liu, L.; Chen, Y.,Electrophoresis of poly(dT)20 through alpha-hemolysin nanopore in high concentration potassium chloridesolution. Journal of Southeast University (English  Edition) 2016,32 (4), 496-501.

32.  Si, W.; Sha, J.; Liu, L.;Zhang,  Y.; Chen, Y. In The moleculardynamics  study for detection of ssDNA bymonolayer graphene nanopore, ASME 2013  InternationalMechanical Engineering Congress and Exposition, IMECE 2013,  November 15, 2013 - November 21, 2013, SanDiego, CA, United states, American Society of Mechanical Engineers (ASME): San Diego, CA, United states,2013; p  V03AT03A046.

33.  Si, W.; Sha, J. J.; Liu, L.;Li,  J. P.; Wei, X. L.; Chen, Y. F.,Detecting DNA Using a Single Graphene Pore by Molecular Dynamics Simulations. Micro-Nano Technology Xiii 2012,503,  423-426.

其他SCI论文

34.  Sarthak,K.; Si, W.; Wilson, J.;Aksimentiev, A. Single-molecule identification of folded proteins from nanoporeionic current signatures. Biophys. J. 2023, 122, 156a-157a.

35.  Zhang,Z.; Chen, M.; Zhan, L.; Zheng, F.; Si,W.; Sha, J.; Chen, Y. Length-Dependent Collective Vibrational Dynamicsin Alpha-Helices. Chemphyschem 2022, 23, e202200082.

36.  Zhan,L.; Zhang, Y.; Si, W.; Sha,J.; Chen, Y. Detection and Separation of Single-Stranded DNA Fragments UsingSolid-State Nanopores. J. Phys. Chem. Lett. 2021, 12, 6469-6477.

37.  Zhang,Y.; Zhao, J.; Si, W.; Kan,Y.; Xu, Z.; Sha, J.; Chen, Y. Electroosmotic Facilitated Protein Capture andTransport through Solid‐State Nanopores with Diameter Larger than Length. SmallMethods 2020, 4, 1900893.

38.  Zhang,Y.; Zhao, J.; Kan, Y.; Ji, R.; Pan, J.; Huang, W.; Xu, Z.; Si, W.; Sha, J. Concentration effects on capture rate andtranslocation configuration of nanopore-based DNA detection. Electrophoresis2020, 41, 1523-1528.

39.  Wilson,J.; Sarthak, K.; Si, W.; Gao,L.; Aksimentiev, A. Rapid and Accurate Determination of Nanopore Ionic CurrentUsing a Steric Exclusion Model. ACS Sens 2019, 4, 634-644.

40.  Ma,J.; Li, K.; Li, Z.; Qiu, Y.; Si, W.;Ge, Y.; Sha, J.; Liu, L.; Xie, X.; Yi, H.; Ni, Z.; Li, D.; Chen, Y. DrasticallyReduced Ion Mobility in a Nanopore Due to Enhanced Pairing and Collisionsbetween Dehydrated Ions. J. Am. Chem. Soc. 2019, 141, 4264-4272.

41.  Yang,H.; Li, Z.; Si, W.; Lin, K.;Ma, J.; Li, K.; Sun, L.; Sha, J.; Chen, Y. Identification of Single Nucleotidesby a Tiny Charged Solid-State Nanopore. J. Phys. Chem. B 2018, 122, 7929–7935.

42.  Winogradoff,D.; Maffeo, C.; Si, W.;Aksimentiev, A. All-Atom Structure and Ionic Conductivity of the Nuclear PoreComplex. Biophys. J. 2018, 114, 630a-630a.

43.  Shi,X.; Li, Q.; Gao, R.; Si, W.;Liu, S. C.; Aksimentiev, A.; Long, Y. T. Dynamics of a Molecular Plug Dockedonto a Solid-State Nanopore. J. Phys. Chem. Lett. 2018, 9, 4686-4694.

44.  Zhang,Y.; Wu, G.; Si, W.; Ma, J.;Yuan, Z.; Xie, X.; Liu, L.; Sha, J.; Li, D.; Chen, Y. Ionic current modulationfrom DNA translocation through nanopores under high ionic strength andconcentration gradients. Nanoscale 2017, 9, 930-939.

45.  Yang,H. J.; Li, Z. W.; Chen, Y. F.; Si, W.Identification of Single Nucleotides in SiN Nanopore. Biophys. J. 2017, 112,25a-25a.

46.  Wolfe,A. J.; Si, W.; Zhang, Z.;Blanden, A. R.; Hsueh, Y. C.; Gugel, J. F.; Pham, B.; Chen, M.; Loh, S. N.;Rozovsky, S.; Aksimentiev, A.; Movileanu, L. Quantification of MembraneProtein-Detergent Complex Interactions. J. Phys. Chem. B 2017, 121,10228-10241.

47.  Shi,X.; Gao, R.; Ying, Y. L.; Si, W.;Chen, Y. F.; Long, Y. T. A Scattering Nanopore for Single Nanoentity Sensing.Acs Sensors 2016, 1, 1086-1090.

48.  Cao,Y.; Lin, Y.; Qian, R. C.; Ying, Y. L.; Si,W.; Sha, J.; Chen, Y.; Long, Y. T. Evidence of single-nanoparticletranslocation through a solid-state nanopore by plasmon resonance energytransfer. Chem. Commun. (Camb.) 2016, 52, 5230-3.

49.  Shi,X.; Gao, R.; Ying, Y. L.; Si, W.;Chen, Y.; Long, Y. T. An integrated system for optical and electrical detectionof single molecules/particles inside a solid-state nanopore. Faraday Discuss.2015, 184, 85-99.

50.  Sha,J. J.; Si, W.; Xu, W.; Zou,Y. R.; Chen, Y. F. Glass capillary nanopore for single molecule detection.Science China-Technological Sciences 2015, 58, 803-812.

51.  Qiu,Y. H.; Li, K.; Chen, W. Y.; Si, W.;Tan, Q. Y.; Chen, Y. F. Ion and water transport in charge-modified graphenenanopores. Chinese Physics B 2015, 24, 108201.

52.  Kan,Y.; Tan, Q.; Wu, G.; Si, W.;Chen, Y. Study of DNA adsorption on mica surfaces using a surface forceapparatus. Sci. Rep. 2015, 5, 8442.

53.  Zhang,Y.; Wu, G. S.; Si, W.; Sha,J. J.; Liu, L.; Chen, Y. F. Retarding and manipulating of DNA moleculestranslocation through nanopores. Chin. Sci. Bull. 2014, 59, 4908-4917.

54.  Zhang,Y.; Wu, G.; Ma, J.; Yuan, Z.; Si, W.;Liu, L.; Sha, J.; Chen, Y. Temperature effect on translocation speed andcapture rate of nanopore-based DNA detection. Sci China Technol Sc 2014, 58,519-525.

55.  Wu,G. S.; Zhang, Y.; Si, W.;Sha, J. J.; Liu, L.; Chen, Y. F. Integrated solid-state nanopore devices forthird generation DNA sequencing. Science China-Technological Sciences 2014, 57,1925-1935.

56.  Qiu,Y. H.; Tan, Q. Y.; Si, W.;Chen, Y. F. Ion specificity in NaCl solution confined in silicon nanochannels.Science China-Technological Sciences 2014, 57, 230-238.

其他EI或会议论文

57.  Ji,Y.; Wang, Y.; Si, W.; Chen,Y. In Molecular dynamics study on the effect of lipid membrane mechanicalproperties on the interaction between β-amyloid and lipid membrane, 2020 14thInternational Conference on Signal Processing and Communication Systems(ICSPCS), 14-16 Dec. 2020; 2020; pp 1-6.

58.  Sun,Q.; Si, W.; Sha, J.; Chen, Y.In Size Characterization of Single Nanoparticles Using Solid-state Nanopores,2019 IEEE International Conference on Manipulation, Manufacturing andMeasurement on the Nanoscale (3M-NANO), 4-8 Aug. 2019; 2019; pp 316-319.

59.  Chen,C.; Si, W.; Wang, G.; Qiao,Y.; Sun, Q.; Sha, J. In MD Simulation for A Double Nanopore DesalinationSystem, 2019 IEEE International Conference on Manipulation, Manufacturing andMeasurement on the Nanoscale (3M-NANO), 4-8 Aug. 2019; 2019; pp 312-315.

60.  Yang,H. J.; Si, W.; Ji, A. P.;Sha, J. J.; Chen, Y. F.; Xie, X.; Ji, A. P.; Ieee, Double Layer NanoporeFabricated by FIB and TEM. In 2017 Ieee International Conference onManipulation, Manufacturing and Measurement on the Nanoscale, Ieee: New York,2017; pp 274-277.

61.  Yu,J.; Si, W.; Sha, J.; Chen, Y.Effect of salt gradients on DNA translocation through solid-state nanopores.Journal of Southeast University (English Edition) 2016, 32, 307-311.

62.  Wu,G.; Zhang, Y.; Si, W.; Gu,Y.; Chen, Y. Current blockade mechanism for DNA translocation throughsolid-state nanopore with different membrane thickness. Journal of SoutheastUniversity (English Edition) 2016, 32, 301-306.

63.  Li,K.; Yuan, Z.; Ji, A.; Si, W.;Lin, K.; Yang, H.; Ma, J.; Sha, J.; Chen, Y. Electrokinetics transport ofconfined electrolyte solution in high concentration. Dongnan Daxue Xuebao(Ziran Kexue Ban)/Journal of Southeast University (Natural Science Edition)2016, 46, 972-976.

64.  Haojie,Y.; Duan, Z.; Si, W.; Li, K.;Chen, Y. In Influence of solution Ph on DNA translocation velocity throughalumina nanopores, ASME 2016 International Mechanical Engineering Congress andExposition, IMECE 2016, November 11, 2016 - November 17, 2016, Phoenix, AZ,United states, American Society of Mechanical Engineers (ASME): Phoenix, AZ,United states, 2016; p American Society of Mechanical Engineers (ASME).

65.  Cai,D.; Kan, Y.; Zhao, G.; Wu, G.; Si, W.;Tan, Q.; Chen, Y. Adsorption and desorption behaviors of ssDNA molecules onmica surface by surface forces apparatus. Journal of Southeast University (EnglishEdition) 2016, 32, 45-50.

66.  Zhang,Y.; Wu, G.; Si, W.; Sha, J.;Liu, L.; Chen, Y. In Nanopore positive pulse detection of DNA with saltgradients, International Conference on Machining, Materials and MechanicalTechnologies, IC3MT 2014, August 31, 2014 - September 5, 2014, Taipei City,Taiwan, Trans Tech Publications Ltd: Taipei City, Taiwan, 2015; pp 567-572.

67.  Sha,J.; Si, W.; Zhang, Y.; Chen,Y. In Concentration gradient effect on the capturing ratio of nanopore for DNA,International Conference on Machining, Materials and Mechanical Technologies,IC3MT 2014, August 31, 2014 - September 5, 2014, Taipei City, Taiwan, TransTech Publications Ltd: Taipei City, Taiwan, 2015; pp 554-560.

68.  Li,K.; Si, W.; Sha, J.; Chen, Y.In Molecular dynamics study of DNA translocation through graphene nanoporeswith controllable speed, ASME 2015 International Mechanical EngineeringCongress and Exposition, IMECE 2015, November 13, 2015 - November 19, 2015,Houston, TX, United states, American Society of Mechanical Engineers (ASME):Houston, TX, United states, 2015; p American Society of Mechanical Engineers(ASME).

69.  Li,K.; Sha, J. J.; Liu, L.; Wu, G. S.; Si,W.; Chen, Y. F. In Molecular Dynamics Study of Confined Fluid inGraphene Nanopores, Advanced Materials Research, Trans Tech Publ: 2015; pp205-208.

70.  Zhang,Y.; Liu, L.; Sha, J.; Si, W.;Ma, J.; Chen, Y. In Fabrication of Al2O3 nanopore sensors for DNA detection,ASME 2013 International Mechanical Engineering Congress and Exposition, IMECE2013, November 15, 2013 - November 21, 2013, San Diego, CA, United states,American Society of Mechanical Engineers (ASME): San Diego, CA, United states,2013; p ASME.

71.  Qiu,Y.; Ma, J.; Guo, W.; Si, W.;Tan, Q.; Chen, Y. In Ionic current investigation in silicon nanochannels withmolecular dynamics simulations, 2013 International Conference on Manipulation,Manufacturing and Measurement on the Nanoscale, 3M-NANO 2013, August 26, 2013 -August 30, 2013, Suzhou, China, IEEE Computer Society: Suzhou, China, 2013; pp325-328.


科研项目
专利

授权发明专利:

1.    司伟,袁润逸,朱振东,沙菁㛃,陈云飞。二维平面异质结构的蛋白质拉伸测序平台及其制备方法。发明专利:202110700951.X2023。(授权)

2.    章寅,赵佳斌,陈云飞,司伟,沙菁㛃。结合纳米孔技术的肿瘤标志miRNA检测装置及方法。发明专利:201910680952 .52023。(授权)

3.    司伟,朱振东,袁润逸,沙菁㛃,陈云飞。一种编码式纳米机器及其控制、制备方法。发明专利:202110700953.92022。(授权)

4.    沙菁㛃,刘巍,司伟,徐伟。DNA多足纳米移动装置及其驱动方法。发明专利:202110270618.X2022。(授权)

5.    司伟,孙倩怡,陈畅,余梦,沙菁㛃,章寅,陈云飞。一种超灵敏塑胶炸弹侦测传感器。发明专利:201911214153.52022。(授权)

6.    司伟,陈畅,孙倩怡,余梦,沙菁㛃,章寅,陈云飞。多自由度自组装纳米机器人及其制作控制方法。发明专利:201911214317.42022。(授权)

7.    章寅,赵佳斌,董隽,陈云飞,司伟,沙菁㛃。一种外泌体内肿瘤标志miRNA的分离和检测系统及方法。发明专利:201910064022.72022。(授权)

8.    沙菁㛃,张志诚,陈云飞,傅方舟,孙倩怡,司伟,章寅。一种基于激光诱导空化的纳尺度薄膜孔制备装置及其方法。发明专利:201910270000.62021。(授权)

9.    沙菁㛃,孙倩怡,张志诚,傅方舟,陈云飞,司伟,章寅。一种光控纳米孔的单分子可控输出装置及其使用方法。发明专利:20181118646362020。(授权)

10.  沙菁㛃,张志诚,陈云飞,孙倩怡,傅方舟,司伟,章寅。纳米孔检测芯片的便携式装夹装置。发明专利:201811328020.62019。(授权)

11.  陈云飞,司伟,伍根生,章寅,沙菁㛃,刘磊。一种多通道阵列式DNA测序系统及其测序方法。发明专利:201410320550.12016。(授权)

12.  陈云飞,倪振华,邹益人,袁志山,赵伟玮,伍根生,徐伟,司伟,沙菁洁,刘磊。一种可控的二维材料柔性转移方法.发明专利:2015.5.28, ZL201510331341.12016。(授权)

13.  陈云飞,司伟,沙菁㛃,刘磊. 一种基于纳米孔和原子力显微镜的三通道并行DNA测序传感器及检测方法.发明专利:201410084787.42015。(授权)

 

申请发明专利:

14.  司伟,张震,沙菁㛃,陈云飞。复合纳米孔生物传感器及其制备方法与应用。发明专利:202310303255.42023。(申请)

15.  沙菁㛃,马超凡,司伟,陈云飞,徐伟,刘巍,徐昌晖。一种电渗流驱动的纳米马达结构。发明专利:202310159496.62023。(申请)

16.  司伟,林晓静,沙菁㛃,陈云飞。一种履带式纳米小车及其控制、制备方法。发明专利:202210355100.02022。(申请)

17.  司伟,王立伟,沙菁㛃,陈云飞。一种纳米管嵌套伸缩式治疗装置及其控制、制备方法。发明专利:202210354772.X2022。(申请)


司伟 机器人技术、流体力学、程序算法、微纳传感
Tel:
Email:wei.si@seu.edu.cn
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Personal Introduction

欢迎优秀的本科生、研究生来课题组垂询体验(例如:竞赛、SRTP项目、毕业设计和攻读研究生学位等),课题组将为各位同学提供个性化的发展规划和优厚的助研津贴与绩效奖励,简历投递邮箱地址wei.si@seu.edu.cn

 

司伟博士,副教授,博导/硕导,医学装备系主任,江苏省优青、江苏省青托,东南大学至善青年学者(A/B层次),江苏省优秀博士学位论文和东南大学优秀博士学位论文获得者,入选东南大学机械工程学院优才培育计划,担任《MaterialsInternational(ISSN: 2668-5728)期刊助理编辑和《Bioengineering International(ISSN 2668-7119)期刊编委。获Nanotechnology期刊杰出审稿人奖、3M Nano国际会议最佳论文奖指导教师、“Electrophoresis” 期刊Reviewer CertificateIOP Trusted Reviewer、闵瑜校友奖励基金等。

主要研究方向:微纳尺度下的(1)机械操控及机器人技术、(2)流体动力学及传感器、(3)结构工艺设计及加工制造、(4)程序语言算法和三维建模与仿真。

教学方面:东南大学第二届“杰出教学奖”教学新秀奖、东南大学第28届青年教师授课竞赛二等奖(每年约前5%可入围)、首届东南大学教师教学创新大赛三等奖,作为项目负责人承担校级教改项目2项,已发表教改论文3篇,担任东南大学机械工程学院本科生班主任,担任东南大学学习优秀生指导教师,担任本科生大类培养指导教师,担任铸造工艺大赛、CIMC“西门子杯中国智能制造挑战赛、本科生工程训练综合能力竞赛指导教师并获得国家级、省部级奖多项,所带的本科毕业设计获得东南大学本科生优秀毕业设计(论文)团队称号,所带的多届本科生毕业设计论文获得机械学院优秀毕业设计论文,所带的本科生SRTP项目获得省级SRTP项目支持,所带的本科班级团支部获东南大学磐石计划校级项目立项。

科研方面:Journal of the American Chemical SocietyACS NanoSmallSmallMethods等国内外期刊发表SCI论文48篇,EI论文23篇,申请和授权发明专利17项,其中以第一作者在ACS NanoSmallSmallMethods等国内外期刊发表SCI论文24(包括IF>10.0SCI论文6篇,封面论文3)。近年来作为主持人承担国家自然科学基金面上项目、国家自然科学青年基金、江苏省基础研究计划(自然科学基金)优秀青年基金、江苏省基础研究计划(自然科学基金)青年基金、江苏省科协青年科技人才托举工程资助项目、南京市留学人员科技创新项目、江苏省仪器仪表学会智能医疗器械创新基金和校企合作基金等多个项目;作为参与人参加研究国家重点研发计划1项,国家自然科学基金重点基金2项和面上基金3项。国际国内作大会报告9次,特邀报告5次。

个人学术主页1https://orcid.org/0000-0001-7285-058X  

个人学术主页2https://www.researchgate.net/profile/Wei-Si-4/research

个人学术主页3https://scholar.google.com/citations?user=J4R73XEAAAAJ&hl=en

五篇代表作(通讯作者论文加*

1.    Si, W.*;Yu, M.; Wu, G.;Chen,  C.; Sha, J.; Zhang, Y.; Chen, Y.,A Nanoparticle-DNA Assembled Nanorobot Powered by Charge-Tunable Quad-Nanopore System. ACS Nano 2020, 14 (11),  15349-15360. (IF17.1)

2.    Si, W.; Aksimentiev, A.,Nanopore  Sensing of Protein Folding. ACSNano 2017,11 (7), 7091-7100. (IF17.1)

3.    Si, W. *; Zhang, Y.; Wu, G.;Kan, Y.; Zhang,  Y.; Sha, J.; Chen, Y.,Discrimination of Protein Amino Acid or Its Protonated  State at Single-Residue Resolution byGraphene Nanopores. Small 2019,15 (14), e1900036. (IF13.3)

4.    Si, W.*; Sun, Q.; Chen,  C.; Yu, M.; Sha, J.; Zhang, Y.; Kan, Y.;Chen, Y., Detergent-Assisted Braking  ofPeptide Translocation through a Single-Layer Molybdenum Disulfide  Nanopore. Small Methods 2020, 1900822.( (IF12.4,封面论文)

5.    Si, W.*; Zhu, Z.; Wu, G.;Zhang, Y.; Chen, Y.; Sha, J. Encoding Manipulation of DNA‐NanoparticleAssembled Nanorobot Using Independently Charged Array Nanopores. Small Methods2022, 6(8): e2200318. (IF12.4)

特邀报告情况:

1.    司伟纳米孔内的流场力及其在纳米机器人驱动中的应用,首届力学交叉前沿研究论坛, 2023-4-212023-4-23,江苏省南京市(大会特邀报告)

2.    司伟基于纳通道的微纳米流体传感与驱动技术,第十六届全国压电和声波理论及器件应用研讨会, 2022-10-112022-10-14,江苏省南京市(大会特邀报告)

3.     司伟DNA过孔操控辅助下的纳米孔测序技术,第一届东南大学先进传感与智能制造国际青年学者论坛,2021-10-292021-10-31,江苏省南京市(大会分会场主席、特邀报告)

4.     Si, W.Controlled translocation of DNA throughsolid-state nanopores for sequencing and manipulation Si, Wei 2021 NanoporeWeekly Meeting, 2021-7-192021-7-19,online(大会特邀报告)

5.     司伟,纳米孔限域在基因类疾病诊疗中的应用,第四届青年科学家论坛——“微纳制造与微纳机器人技术2019614日-16日,黑龙江省哈尔滨工业大学。(大会特邀报告)

其他参加学术会议情况:

6.    司伟纳尺度下的分子运动操控技术,第七届中国微米纳米技术应用创新大会,2022-8-62022-8-8,浙江省杭州市(大会报告)

7.    司伟微纳流体中的单分子驱动操控及纳米机器人研制,中国微米纳米技术学会第五届微流控技术应用创新论坛,2022-7-272022-7-29,广东省广州市(大会报告)

8.       Si, W.; Aksimentiev, A. Nanopore Sensing ofProtein Shape and Folding-Unfolding Transitions. First Conference on Biomotors,Virus Assembly, and Nanobiotecgnology Applications, August 16-19, 2017,Columbus, OH, USA. (Oral presentation)

9.      Si, W.; Aksimentiev, A. Nanopore Ionic Current Can Report on the Folding State of aProtein[J]. Biophysical Society 61stAnnual Meeting, February 11-15, 2017. New Orleans, Louisiana, United States. (Poster presentation)

10.   Si, W.; Yang, H.; Ji, A.; Li,K.; Sha, J.; Liu, L.; Chen, Y. Electrophoresis ofpoly(dT)20 through -hemolysin nanopore in high concentrationpotassium chloride solution. The 17th Annual Conference and 6thInternational Conference of the Chinese Society of Micro-Nano Technology,October 11-14, 2015, Shanghai, China. (Poster presentation)

11.   Si, W.; Sha, J.; Liu,L.; Zhang, Y.; Chen, Y. The Molecular Dynamics Study for Detection of Ssdna byMonolayer Graphene Nanopore[C]. in ASME 2013 International MechanicalEngineering Congress and Exposition, IMECE 2013, November 15, 2013 - November21, 2013. 2013. San Diego, CA, United states: American Society of MechanicalEngineers (ASME). ASME.(Oral presentation)

12.   Si, W.; Sha, J.; Liu, L.; Li,J.; Ge, Y.; Chen, Y., Mechanisms of Pressure-induced water infiltration processthrough graphene nanopores. The 6th Asia-Pacific Conference on Transducersand Micro/Nano Technologies, July 8-11, 2012, Nanjing, China. (Poster presentation)

13.   Si, W.; Sha, J. J.; Liu, L.;Li, J. P.; Wei, X. L.; Chen, Y. F. Detecting DNA Using a Single Graphene Poreby Molecular Dynamics Simulations. 13th Annual Conference of theChinese Socirty of Micro-Nano Technology, September 28-30, 2011, Changzhou, China. (Posterpresentation)


Educational Background

第一作者或通讯作者教学论文(通讯作者论文加*

1.    司伟*,工科专业课教学中课程思政与启发式教学的有机融合. 教书育人(高教论坛) 2021, 110-112.

2.    司伟*,工科专业课程中教师思政教学的意识培养与能力提升. 教书育人(高教论坛)2021, No.760, 45-47.

3.    司伟*,机械设计课堂中的启发式引导教学. 面向一流课程建设的机械原理课程内涵发展与质量提升 2021, 204-206.

第一作者或通讯作者SCI论文(通讯作者论文加*

1.    Si, W.*; Wang, L.; Lin, X.; Wu,G.; Zhang, Y.; Sha, J. A controllable nanoscale telescopic arm designed byencoding the nested multi-walled carbon nanotubes. Phys. Chem. Chem. Phys.2023, 25, 11805-11815.

2.    Ma,C.; Xu, W.; Liu, W.; Xu, C.; Si, W.*;Sha, J. Precise control of CNT-DNA assembled nanomotor using oppositely chargeddual nanopores. Nanoscale 2023, 15, 11052-11063.

3.    Si, W.*; Lin, X.; Wang, L.; Wu,G.; Zhang, Y.; Chen, Y.; Sha, J. Nanopore actuation of a DNA-trackednanovehicle. Nanoscale 2023, 15, 14659-14668.

4.    Si, W.*; Zhu, Z.; Wu, G.;Zhang, Y.; Chen, Y.; Sha, J. Encoding Manipulation of DNA‐NanoparticleAssembled Nanorobot Using Independently Charged Array Nanopores. Small Methods 2022,6(8): e2200318.

5.    Si, W.*; Yuan, R.; Wu, G.; Kan,Y.; Sha, J.; Chen, Y.; Zhang, Y.; Shen, Y. Navigated Delivery of Peptide to theNanopore Using In-Plane Heterostructures of MoS2 and SnS2 for ProteinSequencing. J. Phys. Chem. Lett. 2022, 3863-3872.

6.    Yu,M. #; Si, W. *##并列一作); Zeng, T. #; Chen, C.; Lin, X.;Ji, Z.; Guo, F.; Li, Y.; Sha, J.; Dong, Y. Unveiling the Microscopic Mechanismof Current Variation in the Sensing Region of the MspA Nanopore for DNASequencing. J. Phys. Chem. Lett. 12(37): 9132-9141.

7.    Si, W.*; Yang, H.; Wu, G.;Zhang, Y.; Sha, J. Velocity control of protein translocation through a nanoporeby tuning the fraction of benzenoid residues. Nanoscale 2021, 13(36):15352-15361.

8.    Si, W.*; Chen, C.; Wu, G.; Sun,Q.; Yu, M.; Qiao, Y.; Sha, J. High Efficient Seawater Desalination Based onParallel Nanopore Systems. Nano 2021, 16, 2150077.

9.    Si, W.*;Yu, M.; Wu, G.;Chen,  C.; Sha, J.; Zhang, Y.; Chen, Y.,A Nanoparticle-DNA Assembled Nanorobot Powered by Charge-Tunable Quad-Nanopore System. ACS Nano 2020, 14 (11),  15349-15360.

10.  Si, W.*; Sun, Q.; Chen,  C.; Yu, M.; Sha, J.; Zhang, Y.; Kan, Y.;Chen, Y., Detergent-Assisted Braking  ofPeptide Translocation through a Single-Layer Molybdenum Disulfide  Nanopore. Small Methods 2020, 1900822.(封面论文)

11.  Si, W.*; Yang, H.;  Wu, G.; Chen, C.; Yu, M., Manipulation of DNAtransport through solid-state  nanoporesby atomic force microscopy. Materials Research Express 2020,7 (9), 095404.

12.  Liu,C. #; Si, W. ##并列一作); Wu, C.#; Yang, J.;  Chen, Y.; Dames, C., The ignored effects ofvibrational entropy and  electrocaloriceffect in PbTiO3 and PbZr0.5Ti0.5O3 as studied through  first-principles calculation. Acta Materialia2020,191,  221-229.

13.  Si, W.; Sha, J.; Sun, Q.; He,Z.; Wu, L.; Chen, C.; Yu,  S.-H.; Chen,Y., Shape Characterization and Discrimination of Single  Nanoparticles using Solid-state Nanopores.Analyst 2020,145 (5), 1657-1666. (封面论文)

14.  Si, W.*; Liu, C.; Sha, J.;Zhang, Y.; Chen, Y., Computational modeling of ionic currents through difform graphene nanopores withconsistent  cross-sectional areas. Phys.Chem. Chem. Phys. 2019,21  (47),26166-26174.

15.  Si, W. *; Zhang, Y.; Wu, G.;Kan, Y.; Zhang,  Y.; Sha, J.; Chen, Y.,Discrimination of Protein Amino Acid or Its Protonated  State at Single-Residue Resolution byGraphene Nanopores. Small 2019,15 (14), e1900036.

16.  Si, W.; Yang, H.; Sha, J.;Zhang,  Y.; Chen, Y., Discrimination ofsingle-stranded DNA homopolymers by sieving out G-quadruplex using tiny solid-state nanopores. Electrophoresis 2019,40(16-17), 2117-2124.(封面论文)

17.  Si, W. *; Zhang, Y.; Sha, J. J.;Chen, Y.  F., Mechanisms ofpressure-induced water infiltration process through  graphene nanopores. Mol Simulat 2019,45 (6),518-524.

18.  Si, W.*; Zhang, Y.; Sha, J.;Chen, Y.,  Controllable and reversibleDNA translocation through a single-layer molybdenum disulfide nanopore. Nanoscale 2018,10 (41), 19450-19458.

19.  Sha,J.#; Si, W.##并列一作); Xu, B.; Zhang, S.; Li, K.; Lin, K.; Shi, H.; Chen, Y., Identificationof  Spherical and Nonspherical Proteinsby a Solid-State Nanopore. Anal. Chem. 2018,90 (23),  13826-13831.

20.  Si, W.; Yang, H. J.; Li, K.;Wu,  G. S.; Zhang, Y.; Kan, Y. J.; Xie,X.; Sha, J. J.; Liu, L.; Chen, Y. F., Investigation on the interaction length and access resistance of ananopore  with an atomic forcemicroscopy. Science  China-TechnologicalSciences 2017,60 (4), 552-560.

21.  Si, W.; Aksimentiev, A.,Nanopore  Sensing of Protein Folding. ACSNano 2017,11 (7), 7091-7100.

22.  Si, W.; Aksimentiev, A.,Nanopore  Ionic Current can Report on theFolding State of a Protein. Biophys. J. 2017,112 (3),  195a-195a.

23.  Cressiot,B.#; Greive, S. J.#; Si, W#.#并列一作); Pascoa, T. C.; Mojtabavi,M.;  Chechik, M.; Jenkins, H. T.; Lu, X.;Zhang, K.; Aksimentiev, A.; Antson, A. A.; Wanunu, M., Porphyrin-Assisted Docking of a Thermophage Portal Protein  into Lipid Bilayers: Nanopore Engineering andCharacterization. ACS Nano 2017,11 (12), 11931-11945.

24.  Si, W.; Zhang, Y.; Wu, G. S.;Sha,  J. J.; Liu, L.; Chen, Y. F., DNAsequencing technology based on nanopore sensors by theoretical calculations and simulations. Chinese Science Bulletin2014,59 (35), 4929-4941.

25.  Si, W.; Sha, J. J.; Liu, L.;Qiu,  Y. H.; Chen, Y. F., Effect ofnanopore size on poly(dT)(30) translocation through silicon nitride membrane. Sci. China: Technol. Sci. 2013,56 (10), 2398-2402.

第一作者或通讯作者EI论文(通讯作者论文加*

26.  Zhu,Z.; Si, W.* In Analysis ofElectroosmotic Drive of Double Nanopore Structure, 2022 IEEE InternationalConference on Manipulation, Manufacturing and Measurement on the Nanoscale,3M-NANO 2022, August 8, 2022 - August 12, 2022, Tianjin, China, Institute ofElectrical and Electronics Engineers Inc.: Tianjin, China, 2022; pp 340-343.

27.  Yuan,R.; Si, W.* In ProteinUnfolding with MoS2/SnS2Heterostructure, 2022 IEEE International Conference onManipulation, Manufacturing and Measurement on the Nanoscale, 3M-NANO 2022,August 8, 2022 - August 12, 2022, Tianjin, China, Institute of Electrical andElectronics Engineers Inc.: Tianjin, China, 2022; pp 478-481.

28.  Wang,L.; Si, W.* In The HinderingEffect of the Electric Double Layer during the Retraction of the Inner Wall ofa DWCNT, 2022 IEEE International Conference on Manipulation, Manufacturing andMeasurement on the Nanoscale, 3M-NANO 2022, August 8, 2022 - August 12, 2022,Tianjin, China, Institute of Electrical and Electronics Engineers Inc.:Tianjin, China, 2022; pp 487-490.

29.  Lin,X.; Si, W.* In IonicTransport through Double Nanopores through Simulation, 2022 IEEE InternationalConference on Manipulation, Manufacturing and Measurement on the Nanoscale,3M-NANO 2022, August 8, 2022 - August 12, 2022, Tianjin, China, Institute ofElectrical and Electronics Engineers Inc.: Tianjin, China, 2022; pp 499-502.

30.  Yu,M.; Si, W.*; Sha, J. InMolecular Dynamics Simulation for Protein Unfolding, 2020 IEEE 15thInternational Conference on Nano/Micro Engineered and Molecular System (NEMS),27-30 Sept. 2020; 2020; pp 382-386.

31.  Si, W.; Yang, H.; Ji, A.; Li,K.;  Sha, J.; Liu, L.; Chen, Y.,Electrophoresis of poly(dT)20 through alpha-hemolysin nanopore in high concentration potassium chloridesolution. Journal of Southeast University (English  Edition) 2016,32 (4), 496-501.

32.  Si, W.; Sha, J.; Liu, L.;Zhang,  Y.; Chen, Y. In The moleculardynamics  study for detection of ssDNA bymonolayer graphene nanopore, ASME 2013  InternationalMechanical Engineering Congress and Exposition, IMECE 2013,  November 15, 2013 - November 21, 2013, SanDiego, CA, United states, American Society of Mechanical Engineers (ASME): San Diego, CA, United states,2013; p  V03AT03A046.

33.  Si, W.; Sha, J. J.; Liu, L.;Li,  J. P.; Wei, X. L.; Chen, Y. F.,Detecting DNA Using a Single Graphene Pore by Molecular Dynamics Simulations. Micro-Nano Technology Xiii 2012,503,  423-426.

其他SCI论文

34.  Sarthak,K.; Si, W.; Wilson, J.;Aksimentiev, A. Single-molecule identification of folded proteins from nanoporeionic current signatures. Biophys. J. 2023, 122, 156a-157a.

35.  Zhang,Z.; Chen, M.; Zhan, L.; Zheng, F.; Si,W.; Sha, J.; Chen, Y. Length-Dependent Collective Vibrational Dynamicsin Alpha-Helices. Chemphyschem 2022, 23, e202200082.

36.  Zhan,L.; Zhang, Y.; Si, W.; Sha,J.; Chen, Y. Detection and Separation of Single-Stranded DNA Fragments UsingSolid-State Nanopores. J. Phys. Chem. Lett. 2021, 12, 6469-6477.

37.  Zhang,Y.; Zhao, J.; Si, W.; Kan,Y.; Xu, Z.; Sha, J.; Chen, Y. Electroosmotic Facilitated Protein Capture andTransport through Solid‐State Nanopores with Diameter Larger than Length. SmallMethods 2020, 4, 1900893.

38.  Zhang,Y.; Zhao, J.; Kan, Y.; Ji, R.; Pan, J.; Huang, W.; Xu, Z.; Si, W.; Sha, J. Concentration effects on capture rate andtranslocation configuration of nanopore-based DNA detection. Electrophoresis2020, 41, 1523-1528.

39.  Wilson,J.; Sarthak, K.; Si, W.; Gao,L.; Aksimentiev, A. Rapid and Accurate Determination of Nanopore Ionic CurrentUsing a Steric Exclusion Model. ACS Sens 2019, 4, 634-644.

40.  Ma,J.; Li, K.; Li, Z.; Qiu, Y.; Si, W.;Ge, Y.; Sha, J.; Liu, L.; Xie, X.; Yi, H.; Ni, Z.; Li, D.; Chen, Y. DrasticallyReduced Ion Mobility in a Nanopore Due to Enhanced Pairing and Collisionsbetween Dehydrated Ions. J. Am. Chem. Soc. 2019, 141, 4264-4272.

41.  Yang,H.; Li, Z.; Si, W.; Lin, K.;Ma, J.; Li, K.; Sun, L.; Sha, J.; Chen, Y. Identification of Single Nucleotidesby a Tiny Charged Solid-State Nanopore. J. Phys. Chem. B 2018, 122, 7929–7935.

42.  Winogradoff,D.; Maffeo, C.; Si, W.;Aksimentiev, A. All-Atom Structure and Ionic Conductivity of the Nuclear PoreComplex. Biophys. J. 2018, 114, 630a-630a.

43.  Shi,X.; Li, Q.; Gao, R.; Si, W.;Liu, S. C.; Aksimentiev, A.; Long, Y. T. Dynamics of a Molecular Plug Dockedonto a Solid-State Nanopore. J. Phys. Chem. Lett. 2018, 9, 4686-4694.

44.  Zhang,Y.; Wu, G.; Si, W.; Ma, J.;Yuan, Z.; Xie, X.; Liu, L.; Sha, J.; Li, D.; Chen, Y. Ionic current modulationfrom DNA translocation through nanopores under high ionic strength andconcentration gradients. Nanoscale 2017, 9, 930-939.

45.  Yang,H. J.; Li, Z. W.; Chen, Y. F.; Si, W.Identification of Single Nucleotides in SiN Nanopore. Biophys. J. 2017, 112,25a-25a.

46.  Wolfe,A. J.; Si, W.; Zhang, Z.;Blanden, A. R.; Hsueh, Y. C.; Gugel, J. F.; Pham, B.; Chen, M.; Loh, S. N.;Rozovsky, S.; Aksimentiev, A.; Movileanu, L. Quantification of MembraneProtein-Detergent Complex Interactions. J. Phys. Chem. B 2017, 121,10228-10241.

47.  Shi,X.; Gao, R.; Ying, Y. L.; Si, W.;Chen, Y. F.; Long, Y. T. A Scattering Nanopore for Single Nanoentity Sensing.Acs Sensors 2016, 1, 1086-1090.

48.  Cao,Y.; Lin, Y.; Qian, R. C.; Ying, Y. L.; Si,W.; Sha, J.; Chen, Y.; Long, Y. T. Evidence of single-nanoparticletranslocation through a solid-state nanopore by plasmon resonance energytransfer. Chem. Commun. (Camb.) 2016, 52, 5230-3.

49.  Shi,X.; Gao, R.; Ying, Y. L.; Si, W.;Chen, Y.; Long, Y. T. An integrated system for optical and electrical detectionof single molecules/particles inside a solid-state nanopore. Faraday Discuss.2015, 184, 85-99.

50.  Sha,J. J.; Si, W.; Xu, W.; Zou,Y. R.; Chen, Y. F. Glass capillary nanopore for single molecule detection.Science China-Technological Sciences 2015, 58, 803-812.

51.  Qiu,Y. H.; Li, K.; Chen, W. Y.; Si, W.;Tan, Q. Y.; Chen, Y. F. Ion and water transport in charge-modified graphenenanopores. Chinese Physics B 2015, 24, 108201.

52.  Kan,Y.; Tan, Q.; Wu, G.; Si, W.;Chen, Y. Study of DNA adsorption on mica surfaces using a surface forceapparatus. Sci. Rep. 2015, 5, 8442.

53.  Zhang,Y.; Wu, G. S.; Si, W.; Sha,J. J.; Liu, L.; Chen, Y. F. Retarding and manipulating of DNA moleculestranslocation through nanopores. Chin. Sci. Bull. 2014, 59, 4908-4917.

54.  Zhang,Y.; Wu, G.; Ma, J.; Yuan, Z.; Si, W.;Liu, L.; Sha, J.; Chen, Y. Temperature effect on translocation speed andcapture rate of nanopore-based DNA detection. Sci China Technol Sc 2014, 58,519-525.

55.  Wu,G. S.; Zhang, Y.; Si, W.;Sha, J. J.; Liu, L.; Chen, Y. F. Integrated solid-state nanopore devices forthird generation DNA sequencing. Science China-Technological Sciences 2014, 57,1925-1935.

56.  Qiu,Y. H.; Tan, Q. Y.; Si, W.;Chen, Y. F. Ion specificity in NaCl solution confined in silicon nanochannels.Science China-Technological Sciences 2014, 57, 230-238.

其他EI或会议论文

57.  Ji,Y.; Wang, Y.; Si, W.; Chen,Y. In Molecular dynamics study on the effect of lipid membrane mechanicalproperties on the interaction between β-amyloid and lipid membrane, 2020 14thInternational Conference on Signal Processing and Communication Systems(ICSPCS), 14-16 Dec. 2020; 2020; pp 1-6.

58.  Sun,Q.; Si, W.; Sha, J.; Chen, Y.In Size Characterization of Single Nanoparticles Using Solid-state Nanopores,2019 IEEE International Conference on Manipulation, Manufacturing andMeasurement on the Nanoscale (3M-NANO), 4-8 Aug. 2019; 2019; pp 316-319.

59.  Chen,C.; Si, W.; Wang, G.; Qiao,Y.; Sun, Q.; Sha, J. In MD Simulation for A Double Nanopore DesalinationSystem, 2019 IEEE International Conference on Manipulation, Manufacturing andMeasurement on the Nanoscale (3M-NANO), 4-8 Aug. 2019; 2019; pp 312-315.

60.  Yang,H. J.; Si, W.; Ji, A. P.;Sha, J. J.; Chen, Y. F.; Xie, X.; Ji, A. P.; Ieee, Double Layer NanoporeFabricated by FIB and TEM. In 2017 Ieee International Conference onManipulation, Manufacturing and Measurement on the Nanoscale, Ieee: New York,2017; pp 274-277.

61.  Yu,J.; Si, W.; Sha, J.; Chen, Y.Effect of salt gradients on DNA translocation through solid-state nanopores.Journal of Southeast University (English Edition) 2016, 32, 307-311.

62.  Wu,G.; Zhang, Y.; Si, W.; Gu,Y.; Chen, Y. Current blockade mechanism for DNA translocation throughsolid-state nanopore with different membrane thickness. Journal of SoutheastUniversity (English Edition) 2016, 32, 301-306.

63.  Li,K.; Yuan, Z.; Ji, A.; Si, W.;Lin, K.; Yang, H.; Ma, J.; Sha, J.; Chen, Y. Electrokinetics transport ofconfined electrolyte solution in high concentration. Dongnan Daxue Xuebao(Ziran Kexue Ban)/Journal of Southeast University (Natural Science Edition)2016, 46, 972-976.

64.  Haojie,Y.; Duan, Z.; Si, W.; Li, K.;Chen, Y. In Influence of solution Ph on DNA translocation velocity throughalumina nanopores, ASME 2016 International Mechanical Engineering Congress andExposition, IMECE 2016, November 11, 2016 - November 17, 2016, Phoenix, AZ,United states, American Society of Mechanical Engineers (ASME): Phoenix, AZ,United states, 2016; p American Society of Mechanical Engineers (ASME).

65.  Cai,D.; Kan, Y.; Zhao, G.; Wu, G.; Si, W.;Tan, Q.; Chen, Y. Adsorption and desorption behaviors of ssDNA molecules onmica surface by surface forces apparatus. Journal of Southeast University (EnglishEdition) 2016, 32, 45-50.

66.  Zhang,Y.; Wu, G.; Si, W.; Sha, J.;Liu, L.; Chen, Y. In Nanopore positive pulse detection of DNA with saltgradients, International Conference on Machining, Materials and MechanicalTechnologies, IC3MT 2014, August 31, 2014 - September 5, 2014, Taipei City,Taiwan, Trans Tech Publications Ltd: Taipei City, Taiwan, 2015; pp 567-572.

67.  Sha,J.; Si, W.; Zhang, Y.; Chen,Y. In Concentration gradient effect on the capturing ratio of nanopore for DNA,International Conference on Machining, Materials and Mechanical Technologies,IC3MT 2014, August 31, 2014 - September 5, 2014, Taipei City, Taiwan, TransTech Publications Ltd: Taipei City, Taiwan, 2015; pp 554-560.

68.  Li,K.; Si, W.; Sha, J.; Chen, Y.In Molecular dynamics study of DNA translocation through graphene nanoporeswith controllable speed, ASME 2015 International Mechanical EngineeringCongress and Exposition, IMECE 2015, November 13, 2015 - November 19, 2015,Houston, TX, United states, American Society of Mechanical Engineers (ASME):Houston, TX, United states, 2015; p American Society of Mechanical Engineers(ASME).

69.  Li,K.; Sha, J. J.; Liu, L.; Wu, G. S.; Si,W.; Chen, Y. F. In Molecular Dynamics Study of Confined Fluid inGraphene Nanopores, Advanced Materials Research, Trans Tech Publ: 2015; pp205-208.

70.  Zhang,Y.; Liu, L.; Sha, J.; Si, W.;Ma, J.; Chen, Y. In Fabrication of Al2O3 nanopore sensors for DNA detection,ASME 2013 International Mechanical Engineering Congress and Exposition, IMECE2013, November 15, 2013 - November 21, 2013, San Diego, CA, United states,American Society of Mechanical Engineers (ASME): San Diego, CA, United states,2013; p ASME.

71.  Qiu,Y.; Ma, J.; Guo, W.; Si, W.;Tan, Q.; Chen, Y. In Ionic current investigation in silicon nanochannels withmolecular dynamics simulations, 2013 International Conference on Manipulation,Manufacturing and Measurement on the Nanoscale, 3M-NANO 2013, August 26, 2013 -August 30, 2013, Suzhou, China, IEEE Computer Society: Suzhou, China, 2013; pp325-328.


Professional Experience

1.MaterialsInternational(ISSN: 2668-5728)期刊助理编辑

2.《BioengineeringInternational(ISSN 2668-7119)期刊编委


Teaching
Research Interests

授权发明专利:

1.    司伟,袁润逸,朱振东,沙菁㛃,陈云飞。二维平面异质结构的蛋白质拉伸测序平台及其制备方法。发明专利:202110700951.X2023。(授权)

2.    章寅,赵佳斌,陈云飞,司伟,沙菁㛃。结合纳米孔技术的肿瘤标志miRNA检测装置及方法。发明专利:201910680952 .52023。(授权)

3.    司伟,朱振东,袁润逸,沙菁㛃,陈云飞。一种编码式纳米机器及其控制、制备方法。发明专利:202110700953.92022。(授权)

4.    沙菁㛃,刘巍,司伟,徐伟。DNA多足纳米移动装置及其驱动方法。发明专利:202110270618.X2022。(授权)

5.    司伟,孙倩怡,陈畅,余梦,沙菁㛃,章寅,陈云飞。一种超灵敏塑胶炸弹侦测传感器。发明专利:201911214153.52022。(授权)

6.    司伟,陈畅,孙倩怡,余梦,沙菁㛃,章寅,陈云飞。多自由度自组装纳米机器人及其制作控制方法。发明专利:201911214317.42022。(授权)

7.    章寅,赵佳斌,董隽,陈云飞,司伟,沙菁㛃。一种外泌体内肿瘤标志miRNA的分离和检测系统及方法。发明专利:201910064022.72022。(授权)

8.    沙菁㛃,张志诚,陈云飞,傅方舟,孙倩怡,司伟,章寅。一种基于激光诱导空化的纳尺度薄膜孔制备装置及其方法。发明专利:201910270000.62021。(授权)

9.    沙菁㛃,孙倩怡,张志诚,傅方舟,陈云飞,司伟,章寅。一种光控纳米孔的单分子可控输出装置及其使用方法。发明专利:20181118646362020。(授权)

10.  沙菁㛃,张志诚,陈云飞,孙倩怡,傅方舟,司伟,章寅。纳米孔检测芯片的便携式装夹装置。发明专利:201811328020.62019。(授权)

11.  陈云飞,司伟,伍根生,章寅,沙菁㛃,刘磊。一种多通道阵列式DNA测序系统及其测序方法。发明专利:201410320550.12016。(授权)

12.  陈云飞,倪振华,邹益人,袁志山,赵伟玮,伍根生,徐伟,司伟,沙菁洁,刘磊。一种可控的二维材料柔性转移方法.发明专利:2015.5.28, ZL201510331341.12016。(授权)

13.  陈云飞,司伟,沙菁㛃,刘磊. 一种基于纳米孔和原子力显微镜的三通道并行DNA测序传感器及检测方法.发明专利:201410084787.42015。(授权)

 

申请发明专利:

14.  司伟,张震,沙菁㛃,陈云飞。复合纳米孔生物传感器及其制备方法与应用。发明专利:202310303255.42023。(申请)

15.  沙菁㛃,马超凡,司伟,陈云飞,徐伟,刘巍,徐昌晖。一种电渗流驱动的纳米马达结构。发明专利:202310159496.62023。(申请)

16.  司伟,林晓静,沙菁㛃,陈云飞。一种履带式纳米小车及其控制、制备方法。发明专利:202210355100.02022。(申请)

17.  司伟,王立伟,沙菁㛃,陈云飞。一种纳米管嵌套伸缩式治疗装置及其控制、制备方法。发明专利:202210354772.X2022。(申请)


Refereed Journals
Other Professional Activities
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Research Projects
Patents and Applications